drosophila neurobiology Lab @NCCS
Publications
Biomolecular condensates of Eya drive transcriptional co-activation associated with eye development
Nilanjana Das, Janhavi Bapat, Amitabha Majumdar
bioRxiv 2025.10.15.682020; doi: https://doi.org/10.1101/2025.10.15.682020
Pathogenic Huntingtin aggregates alter actin organization and cellular stiffness resulting in stalled clathrin mediated endocytosis.
Surya Bansi Singh, Shatruhan Singh Rajput, Aditya Sharma, Sujal Kataria, Priyanka Dutta, Vaishnavi Ananthanarayanan, Amitabha Nandi, Shivaprasad Patil, Amitabha Majumdar, Deepa Subramanyam (2024) eLife 13:e98363.
https://doi.org/10.7554/eLife.98363
Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
Desai M, Hemant, Deo A, Naik J, Dhamale P, Kshirsagar A, Bose T, Majumdar A
PLoS Biol. 2024 Apr 22;22(4):e3002585. doi: 10.1371/journal.pbio.3002585.
https://doi.org/10.1371/journal.pbio.3002585
Mrj an Hsp40 family chaperone regulates the oligomerization of Orb2 and long-term memory
Desai M, Hemant, Deo A, Naik J, Bose T, Majumdar A
bioRxiv 2022.10.16.512122; doi: https://doi.org/10.1101/2022.10.16.512122
A role of cellular translation regulation associated with toxic Huntingtin protein
Joag H, Ghatpande V, Desai M, Sarkar M, Raina A, Shinde M, Chitale R, Deo A, Bose T, Majumdar A
Cell. Mol. Life Sci. 77, 3657–3670 (2020). https://doi.org/10.1007/s00018-019-03392-y
(earlier version: https://www.biorxiv.org/content/10.1101/687764v1, doi: https://doi.org/10.1101/687764)
Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.
Hervás R, Li L, Majumdar A, Fernández-Ramírez Mdel C, Unruh JR, Slaughter BD, Galera-Prat A, Santana E, Suzuki M, Nagai Y, Bruix M, Casas-Tintó S, Menéndez M, Laurents DV, Si K, Carrión-Vázquez M.
PLoS Biol. 2016 Jan 26;14(1):e1002361. doi: 10.1371/journal.pbio.1002361. eCollection 2016 Jan.
Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memory.
Majumdar A, Cesario WC, White-Grindley E, Jiang H, Ren F, Khan MR, Li L, Choi EM, Kannan K, Guo F, Unruh J, Slaughter B, Si K.
Cell. 2012 Feb 3;148(3):515-29. doi: 10.1016/j.cell.2012.01.004. Epub 2012 Jan 26.
Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation.
Si K, Choi YB, White-Grindley E, Majumdar A, Kandel ER.
Cell. 2010 Feb 5;140(3):421-35. doi: 10.1016/j.cell.2010.01.008.